small animal clinical pharmacology
NO then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate cGMP producing smooth muscle. Volunteers are given an extremely small one-time drug dose and sophisticated imaging techniques are used to monitor how the drug behaves in the body.
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Microdosing can replace certain tests on animals and help screen out drug compounds that wont work in humans so.
. Viagra - Clinical Pharmacology Mechanism of Action. Learn more about state-of-the-art animal testing alternatives like in vitro and in silico methods. The physiologic mechanism of erection of the penis involves release of nitric oxide NO in the corpus cavernosum during sexual stimulation.
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